Prevention and treatment of lifestyle diseases – Targetello project

The project is implemented as part of the STRATEGMED programme Prevention and treatment of lifestyle diseases.

The scientific aim of the project was to design novel anti-cancer drug candidates. The research was carried out in collaboration with scientists from Gdańsk University of Technology, Medical University of Gdańsk and University of Gdańsk to develop new anti-cancer therapies. Teams led by prof. Michał Bagiński (Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology), prof. Rafał Bartoszewski (Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk), prof. Michał Markuszewski (Department of Biopharmacy and Pharmacodynamics, Medical University of Gdańsk) prof. Piotr Skowron (Department of Molecular Biotechnology, University of Gdańsk) and Agnieszka Chylewska, PhD, prof. of University of Gdańsk (Department of Bioinorganic Chemistry).

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The scientists searched for molecules that could interfere with uncontrolled cell divisions, which is characteristic for cancer cells, and thus enable the development of specific anti-cancer therapies.

The project research goals involved bioinformatic modeling of molecules with specific biological activity followed by evaluation of their mechanisms of action at the molecular level, and the risk of potential side effects. During the project, besides the identification of novel drug candidates, the researchers have gained information on new, previously unknown properties of the studied compounds.

The researchers agreed on the importance of interdisciplinary collaboration for this project.

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